Numerical Simulations of a Transient Transonic Gas Flow for DNA Vaccine Ballistic Delivery
نویسندگان
چکیده
By means of a transient transonic helium jet generated by a convergent-divergent conical nozzle, a unique biolistic method of accelerating microparticle formulations of DNA vaccines or drugs to penetrate the outer layer of human skin or mucosal tissue to elicit an physiological response for the treatment of a range of diseases. In this paper, Computational Fluid Dynamics is utilized to predict the performance of a prototype biolistics delivery system. Simulated pressure histories, Mach number distributions and twodimensional flow structures agree well with the corresponding experimental measurements. It is demonstrated that the shock waves and shock/boundary layer interactions are accurately captured with the present numerical approach.
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